Pengaruh Pemberian Virgin Coconut Oil (Vco) Enzimatis terhadap Gambaran Histopatologi Hati Tikus Putih Jantan Model Hiperkolesterolemia Diabetes

Penulis

  • Niluh Puspita Dewi Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
  • Nani Ekawati Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
  • Joni Tandi Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu

Kata Kunci:

Enzymatic VCO, Liver Histopathology, Diabetes Hypercholesterolemia.

Abstrak

Abstract 

Background: The life of modern society that is instantaneous by ignoring a healthy lifestyle is the cause of the risk of degenerative diseases. One of the degenerative diseases that tend to increase is hypercholesterolemia. The accumulation of cholesterol in the body can lead to insulin resistance resulting in an increase in blood glucose levels which   triggers   type   2   diabetes   mellitus   (DM).   Uncontrolled   DM   can   cause complications  in various organ systems  such as hepatopathy. 

Objective: This study aims to examine the histopathological  description of the liver of male hypercholesterolemic diabetic white rats given enzymatic VCO.

Method: This research was experimental with a pre- test and post-test completely randomized design. The research subjects were thirty male rats divided into six groups, namely: normal control, negative control, positive control, dose group 0.2, 0.4, and 0.8 mL/200g BW.

Results: The results showed that changes in the histopathological  pictures of the liver in the form of hydropic,  necrotic, and apoptotic degeneration  increased in the negative control, among the group with a dose of 0.2, 0.4, and 0.8 mL/200g BW with the average value 2, 1.6, and 1.2 respectively from the highest score the damage of 2.

Conclusion: Enzymatic VCO administration did not give maximum results in improving the liver picture of male white rats.

 

 

Referensi

Angrella, N., Indrawati, R., & Dewi, L, "Pengaruh Pemberian Virgin Coconut Oil Terhadap Kadar Kreatinin dan Urea Nitrogen Darah Rattus norvegicus Jantan", Hang Tuah Medical Journal., 17(2), 181-191, 2020.

Anugrah, T, "Efek ekstrak daun Moringa oleifera terhadap gambaran histopatologik hepar tikus Sprague dawley yang diinduksi streptozotocin" (Bachelor's thesis, Fakultas Kedokteran Universitas Islam Negeri Syarif Hidayatullah Jakarta), 2019.

DepKes, RI, "Pedoman Pengendalian Diabetes Melitus dan Penyakit Metabolik". Jakarta: Departemen Kesehatan RI, 2018

Dewi, NP., Windi Olivia Dan Debora Rislianti, "Studi Histopatologi Regenerasi Hepar Tikus Wistar Yang Diinduksi Streptozotocin Setelah Pemberian Ekstrak Etanol Daun Labu Kuning (Cucurbita Moschata Duchesne)", Ad-Dawaa'Journal of Pharmaceutical Sciences 4 (2), 2021

Hendri, A., dan Refelita, F, "Pembuatan Virgin Coconut Oil dengan Bantuan Enzim Bromelain sebagai Alternatif Praktikum di SMAN Kampar", Konfigurasi: Jurnal Pendidikan Kimia dan Terapan,, 1(1), 121-128.

Ishak, I., Aji, A., & Israwati, "Pengaruh Waktu Fermentasi dan Berat Bonggol Nanas Pada Pembuatan Virgin Coconut Oil (VCO)", Jurnal Teknologi Kimia Unimal., 8(1), 57-68, 2020.

Kintoko, K., Balfas, R. F., Ustrina, N., Widyarini, S., Saputri, L. C., Nurwijayanti, A .,& Anggraini, N. T, "Efek Anti Diabetes Spirulina Platensis Terhadap Analisis Kadar, Gambaran Histopatologi, Ekspresi Insulin dan Glucose Transpoter 4 Pada Tikus Putih Wistar yang Diinduksi Streptozopin", Jurnal Ilmu Kefarmasian Indonesia., 16(2), 238-247, 2018.

Manatar, A. F., Wangko, S., & Kaseke, M. M, "Gambaran Histologik Hati Tikus Wistar yang Diberi Virgin Coconut Oil dengan Induksi Parasetamol", Jurnal Biomedik., JBM, 5(1), 2013.

Palilingan, S. C., dan Pungus, M, "Produksi enzimatis Virgin Coconut Oil (VCO) dengan enzim bromelin serta pemurniannya menggunakan adsorben zeolit", Fullerene Journal of Chemistry., 3(2), 70-74, 2018.

Rachmawani, N. R., & Oktarlina, R. Z. (2017). Khasiat Pemberian Buncis (Phaseolus vulgaris L.) sebagai Terapi Alternatif Diabetes Melitus Tipe 2. Jurnal Majority, 6(1), 71-76.

Riyanto, H. A, "Identifikasi Komplikasi Pada Pasien Diabetes Mellitus di Puskesmas Kalijudan Surabaya", Doctoral dissertation, Universitas Muhammadiyah Surabaya, 2018

Rizza, I. P, "Uji Aktivitas Antioksidan Pada Vco (Virgin Coconut Oil) Kelapa Bibir Merah (Cocos nucifera L Var rubescens.)", (Doctoral dissertation, UIN Raden Intan Lampung).

Rochmawati, A., & Ardiansyah, S, "Uji Aktivitas Antidiabetes Ekstrak Bonggol Nanas (Ananas comusus L.) pada Tikus yang Di induksi Aloksan", Medicra (Journal of Medical Laboratory Science/Technology)., 1(1), 36-43 2018.

Manullang, R. S., & Hutapea, V. (2014). Pembuatan virgin coconut oil (vco) melalui kombinasi teknik fermentasi dan enzimatis menggunakan ekstrak nenas. Jurnal pendidikan kimia, 6(1), 91-100.

Tandi, J, "Uji Efek Ekstrak Ekstrak Etanol Daun Sukun (Artocarpus Altilis (Parkinson Ex F.A.Zorn) Terhadap Penurunan Kadar Glukosa Darah, Kolestrol Total Dan Gambaran Histopatologi Pakreas Tikus Putih Jantan (Rattus Norvegicus) Hiperkolestrolemia-Diabetes’", Sains Dan Kesehatan., 1(8), Pp. 384–396, 2018.

Tandi J, "Effect Of Ethanol Extract Gendola Leaf (Basella alba) On Decreasing Blood Glucose Condition And Hsitopatology Pancreas White Male Rats (Rattus norvegicus) Indicated Streptozotocin", JIMR-Journal Of Islamic Medicine., Research Volume 1, No.2. Hal 15-25, 2017.

Utari, "Uji Efek Protektif Virgin Coconut Oil Dan Extra Virgin Olive Oil Serta Kombinasinya Dalam Mengurangi Kardiotoksisitas Akibat Doksorubisin Pada Tikus", (Doctoral dissertation, Universitas Hasanuddin), 2021.

Yuniwarti, E. Y. W., Saraswati, T. R., dan Kusdiyantini, E., "Respon Penurunan Kadar Glukosa Darah Tikus (Rattus norvegicus) Hiperglikemik Setelah Pemberian Berbagai Minyak Konsumsi", Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology)., 3(2), 146-149, 2018.

Unduhan

Diterbitkan

2023-01-21

Terbitan

Vol 1 No 1 (2023)

Bagian

Articles

Lisensi

Hak Cipta (c) 2023 Niluh Puspita Dewi

Creative Commons License

Artikel ini berlisensiCreative Commons Attribution-ShareAlike 4.0 International License.

Indonesian Journal of Pharmaceutical Sciences and Clinical Research (IJPSCR)allows readers to read, download, copy, distribute, print, search, or link to its articles' full texts and allows readers to use them for any other lawful purpose. The journal allows the author(s) to hold the copyright without restrictions. Finally, the journal allows the author(s) to retain publishing rights without restrictions
  • Authors are allowed to archive their submitted article in an open access repository
  • Authors are allowed to archive the final published article in an open access repository with an acknowledgment of its initial publication in this journal


This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 Generic License.

 

Â